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Because of the tumor generating nature of the disorder and its involvement of the nervous system and also because of early onset macrocephaly in the pediatric population, there is often an increased chance of development of epilepsy in those affected.

The disorder affects all neural crest cells (Schwann cells, melanocytes and endoneurial fibroblasts).

Cellular elements from these cell types proliferate excessively throughout the body, forming tumors; melanocytes also function abnormally in this disease, resulting in disordered skin pigmentation and “cafe-au-lait” spots.

Patients with neurofibromatosis can be affected in many different ways.

Morbidity is often a result of plexiform neuromas, optic gliomas, or acoustic neuromas, but mortality can also be associated with malignant transformation of the neuromas, such as neurofibrosarcomas in patients with NF, particularly NF-1, however severe retardation is not part of the syndrome.

The tumors may cause bumps under the skin, colored spots, skeletal problems, pressure on spinal nerve roots, and other neurological problems.

Neurofibromatosis is an autosomal dominant disorder, which means only one copy of the affected gene is needed for the disorder to develop.

It is also caused by a mutation in a tumor suppressor gene (NF2 or merlin).

The normal function of merlin is not well understood.

In the case of NF1, no clear links between genotype and phenotype have been found, and the severity and the specific nature of the symptoms may vary widely among family members with the disorder.

This is a good example of the phenomenon of variable expressivity: the differing severities of disease in different individuals with the same genotype.

If anyone sees a case like this in his home environment, I hope to help by submitting photos of patients with a short history I hope this paper, which is part of my essay book entitled “KNOW AND OVERCOMING MEDICAL ANOMALY” SHOULD, LIKE THIS CASE DOES NOT NEED TO HAPPEN, IF PEOPLE KNOW PERKEMABNAGN DISEASE (PAOGENESIS) MEDICAL AND EFFORT THAT CAN BE EXECUTED.