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Psp updating modified memory

The disorder’s long name indicates that the disease worsens (progressive) and causes weakness (palsy) by damaging certain parts of the brain above nerve cell clusters called nuclei (supranuclear). One of the classic signs of the disease is an inability to aim and move the eyes properly, which individuals may experience as blurring of vision.

As the disease progresses, most people will begin to develop a blurring of vision and problems controlling eye movement.

In fact, eye problems, in particular slowness of eye movements, usually offer the first definitive clue that PSP is the proper diagnosis.

Genetic factors have not been implicated in most individuals. A central hypothesis in many neurodegenerative diseases is that once the abnormal aggregates of proteins like tau form in a cell, they can affect a connected cell to also form the protein clumps.

In this way the toxic protein aggregates spreads through the nervous system. One possibility is that an unconventional infectious agent takes years or decades to start producing visible effects (as is seen in disorders like Creutzfeldt-Jakob Disease).

Although individuals with Parkinson's disease markedly benefit from the drug levodopa, people with PSP respond minimally and only briefly to this drug.

Also, people with PSP show accumulation of the protein tau in affected brain cells, while people with Parkinson’s disease show accumulation of a different protein, called alpha-synuclein. The symptoms of PSP are caused by a gradual deterioration of brain cells in a few specific areas in the brain, mainly in the region called the brain stem.

Currently there is no effective treatment for PSP, but some symptoms can be managed with medication or other interventions.

It was sometimes referred to as Steele-Richardson-Olszewski syndrome, reflecting the combined names of the scientists who defined the disorder.

Progressive supranuclear palsy (PSP) is an uncommon brain disorder that affects movement, control of walking (gait) and balance, speech, swallowing, vision, mood and behavior, and thinking.

Individuals may have unexplained falls or a stiffness and awkwardness in gait.

Since many symptoms of PSP are also seen in individuals with Parkinson’s disease, particularly early in the disorder, PSP is often misdiagnosed as Parkinson’s disease.

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30-Mar-2020 13:15

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